Abstract

The main objective of this research was to determine and correlate the equilibrium solubility of sodium sulfamethazine (NaSMT) in several {ethanol (1) + water (2)} mixtures reported in mass/volume and mass/mass percentages at different temperatures, as well as the density of saturated solutions. NaSMT solubility decreases with decreasing temperature, and also decreases non-linearly with the addition of ethanol to water at every temperature. Logarithmic solubility was adequately correlated with a bivariate model involving temperature and mixture composition. Solubility values were also well correlated with some Jouyban–Acree-based models. Moreover, an adapted version of the Jouyban–Acree model was used to represent the density of the saturated systems at different temperatures. Furthermore, the apparent specific volumes of NaSMT at saturation were also calculated from densities of saturated solutions and cosolvent mixtures free of drug at every mixture composition and temperature. These findings provide valuable insights into the solubility and volumetric behavior of NaSMT that could be useful for improving pharmaceutical formulation processes.

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