Abstract

Segmentation of bone marrow lesions (BML) is vital for quantifying lesion volume, a biomarker associated with cartilage damage and pain in knee osteoarthritis (KOA). Manual segmentation is challenging due to low contrast and variable lesion locations. We propose an automated deep learning method featuring a dual-stream encoder that integrates global image-level and local patch-level features. The study included 300 participants from the Osteoarthritis Initiative (OAI) database, each with approximately 36 intermediate-weighted fat-suppressed (IWFS) magnetic resonance (MR) images. The ground truth masks were manually annotated by trained research staff. With physical batch size 32, the model achieved a 2D Dice similarity coefficient (DSC) of 0.68, 3D DSC of 0.62, Intersection over Union (IoU) of 0.51, precision of 0.76, sensitivity of 0.62, and Pearson’s correlation coefficient (r) of 0.85 between manually labelled and automatically generated volumes. Using an effective batch size of 64 via gradient accumulation, the model achieved 2D DSC of 0.63, 3D DSC of 0.65, IoU of 0.48, precision of 0.75, sensitivity of 0.6, and r of 0.98 for volume correlation. The model outperformed baselines at batch size 32 across almost all evaluated metrics and remained robust at batch size 64, with strong volumetric correlation and improved 3D DSC, IoU, and sensitivity.

IPC Classification

Keywords