Abstract

Background: Cutaneous microcirculation is crucial for skin appearance and rejuvenation, influencing color, luminosity and texture. Aging reduces microcirculation and alters skin color parameters. This study investigated the long-term effects of intradermal CellBooster® Lift (CBL), a mechanically stabilized hyaluronic acid complex enriched with amino acids and vitamins, on skin microcirculation, color, and aesthetics in healthy adults. This study was registered at clinicaltrial.gov (NCT06000839). Methods: 36 women and 4 men aged 35–55 received three intradermal injections of 3 mL CBL across the face at two-week intervals. Cutaneous microcirculation was assessed using a PeriFlux 5000® laser Doppler system at 7 and 84 days post-treatment. Skin color parameters, including lightness (L*), redness (a*), yellow-blue component (b*), individual typology angle (ITA°), individual whitening angle (IWA°), color homogeneity (H76), saturation, and luminance-saturation ratio, were analyzed using Visia® CR 2D imaging. Aesthetic improvement was evaluated by both participants and medical practitioners using the Global Aesthetic Improvement Scale (GAIS). Results: At 84 days post-treatment, CBL significantly enhanced cutaneous microcirculation and induced favorable changes in all measured skin color parameters: L*, ITA°, IWA°, and luminance-saturation ratio increased, while a*, b*, H76, and saturation decreased in women, but no changes were seen in men. No significant differences were observed between female age groups. On the GAIS, approximately 70–73% of participants reported improvement or significant improvement, while medical practitioners rated improvement in up to 93% of cases. Conclusions: Intradermal CBL administration improves cutaneous microcirculation and skin color characteristics, contributing to a more youthful appearance in adults aged 35–55, with consistent effects across age groups and high subjective and clinical aesthetic ratings.

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