Abstract

Nucleic acids exhibit structured electromagnetic features shaped by classical electronegativity (EN) patterns. Mapping Pauling EN values across DNA and RNA reveals a largely invariant, high-EN phosphodiester backbone that provides a consistent electrostatic scaffold, while nucleobases introduce sequence-specific electron density shifts that generate tunable recognition fields. Together, these features create a dual-system framework in which a stable electrostatic background supports sequence-dependent informational cues. Within this environment, short-timescale vibronic interactions may arise from patterned vibrational and electronic behavior, producing modest “quantum overlay” effects compatible with known decoherence constraints. These structured, anisotropic electrostatic features may help explain differences in stability between DNA and RNA, the functional outcomes of nucleoside modifications such as N1-methylpseudouridine (m1Ψ), and the sensitivity of translational fidelity to small architectural perturbations. The framework yields experimentally testable predictions involving vibrational relaxation, dipole reorientation, and charge-transfer behavior, offering a classical-to-quantum interpretive bridge that may inform the design of next-generation therapeutic mRNAs.

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