Abstract

Intrinsic and extrinsic skin aging alter skin structure and function, while hydrating products and regenerative therapies such as platelet-rich plasma (PRP) support the restoration of skin homeostasis and clinical appearance. This in vivo study aimed to evaluate whether a combination of a hydrating cream and PRP improves skin texture. Three groups of participants were treated over 90 days with hydrating cream, intradermal PRP, and hydrating cream enriched with PRP (HC-PRP). The evaluation was conducted by dermoanalysis at each 30 days with two main indices, moisture and texture, and six complementary indices, oil, complexion, 3D, pigment, phlogosis, and pores. The best texture outcomes were observed in the HC-PRP group, which showed a significant improvement over time and better results than the cream alone (significant after Bonferroni correction). For the moisture index, the hydrating cream alone gave the largest increase, consistent with its primary action, although HC-PRP was also associated with a moderate increase. These exploratory results point to a potential benefit of the HC-PRP combination for skin texture and offer a starting point for future research. Further randomized studies on larger samples are required to validate these observations and to establish the contribution of PRP.

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